Toggle Large-File Mode (active file)
view.toggleLargeFileMode Turn the minimap and language server off (or back on) for the current file to keep a huge file responsive.
How to run it
Open the command palette (M-x in the Emacs keymap) and search for Toggle Large-File Mode (active file), then press Enter. It has no default keybinding, but you can bind one in Settings → Keymaps.